![]() ![]() ![]() However, while the impact of inflammatory challenges on the negative affect component of depression has been examined, the impact of inflammation on other accompanying behaviours has often been overlooked. However, the additive nature of inflammation-induced depressive-like behaviours when combined with MDD highlights that inflammation is likely to be clinically relevant tractable target in many clinical forms of depression. Tumour necrosis factor alpha (TNFα) blockade, for example, improved depressive symptoms in patients with treatment-resistant depression, but only in patients with high baseline CRP levels, suggesting that the anti-inflammatory therapy targets processes independent of the etiological mechanisms underlying major depressive disorder (MDD). Indeed, clinical trials have reported antidepressant treatment effects for anti-inflammatory agents such as non-steroidal anti-inflammatory drugs (NSAIDs), and pro-inflammatory cytokine inhibitors have also shown antidepressant treatment effects compared to placebo. The association between depression and inflammation has been recognized for some time. However, at a time when LPS alone does not induce any overt behavioural changes per se, the combination with stress exacerbates depressive and inhibits aggressive behaviours. It is evident that when administered independently, both stress and LPS challenges induced distinct molecular and behavioural changes. Stress did not induce comparable levels of cytokine expression to an LPS challenge, but the combination of stress with LPS reduced the stress-induced changes in 5-HT genes and the LPS-induced elevated IL-1β levels. ![]() There was also increased serum corticosterone as well as increased TNFα expression in the liver. At the molecular level, LPS was a strong inducer of TNFα, IL-1β and region-specific 5-HT 2A mRNA expression in the brain. When combined with a low dose of LPS, chronic stress resulted in an enhanced depressive-like phenotype but significantly reduced manifestations of aggression and hyperactivity. MethodsĬhanges in measures of hedonic sensitivity, helplessness, aggression, impulsivity and CNS and systemic cytokine and 5-HT-system-related gene expression were investigated in C57BL/6J male mice exposed to chronic stress alone, low-dose LPS alone or a combination of LPS and stress. Here, we examined whether stress-induced behavioural and molecular responses are analogous to lipopolysaccharide (LPS)-induced behavioural and molecular effects and whether their combination is adaptive or maladaptive. However, chronic mild stress (CMS) and clinically silent inflammation, during the recovery period after an infection, for example, are often coincident, but comparison of the behavioural and molecular changes that underpin CMS vs a mild inflammatory challenge and impact of the combined challenge is largely unexplored. Aggression, hyperactivity, impulsivity, helplessness and anhedonia are all signs of depressive-like disorders in humans and are often reported to be present in animal models of depression induced by stress or by inflammatory challenges. ![]()
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![]() ![]() ![]() Instead of fearing that something bad will happen, the person with Counting OCD feels the need for something to be done the “right” amount of times or according to some rigid rules. Sometimes the obsessive concern is more vague. Annie, the girl from the scenario at the beginning of this article was an example of someone with fear-related counting. The obsessive concern might be that something bad will happen to themselves or to someone they care about. More often, counting is a compulsive behavior, meaning that it is in response to an obsession that creates anxiety. Instead, it can trigger an obsessive fear like: “ What if I can’t ever stop counting?” This is similar to obsessive fears people have about being distracted by something like swallowing or blinking, or maybe a ringing in their ears. The counting is not often in response to an obsessive thought. People with Counting OCD might count anything at all, including thoughts, actions, or simply numbers on their own. Learn more What might people with OCD compulsively count? You’re not on your own, and you can talk to a specialist like me who has experience treating compulsive counting. Adding to or repeating behavior sets as many times as necessary to avoid “bad” numbers.ĭo these symptoms sound familiar? Learn how you can overcome them.Īs an OCD specialist, I know how overwhelming compulsive counting can be-and how quickly these symptoms can spread to every part of your life.Doing actions in sets of a particular number (e.g., looking at things or performing other behaviors in a specified series, like sets of three).Counting to whatever number happens to feel “right” at that moment. ![]() This can be done once, or over and over again. Some common, specific forms of counting that I’ve helped people deal with through treatment include: Common Counting BehaviorsĬounting OCD can manifest in a variety of ways. The worry and anxiety that Annie felt in the moment were enough to overwhelm her rational beliefs and understanding. She did things like tap her hand on the armrest of the couch seven times, click her heels together seven times, and move her head to one side and back again seven times.Īnnie knew that none of this made sense rationally, but there is nothing rational about OCD. In response, she started her familiar ritual of mentally counting to seven over and over again. In one instance, when she learned that her mother was on her way home from the airport, Annie’s mind shifted to a familiar obsessive thought: “ What if mom gets into an accident?”Īnnie felt the pit of anxiety in her stomach and noticed her heart beating faster. One person I’ve worked with in therapy-let’s call her Annie-saw her Counting OCD triggered when she feared her mother would get in a car accident during her commute home. For example, if you assign special meaning to the number three, you might count your steps by threes, or lock and unlock your car three times before driving, or any variety of other actions ruled by this “magic number.” In some cases, people may feel a responsibility to prevent something bad from happening to themselves or to others and they count to try and guarantee safety-even though they know it doesn’t make sense. Sometimes Counting OCD is driven by attaching meaning to particular numbers where certain numbers will induce anxiety, while others will reduce anxiety. Sometimes the counting is automatic-without thinking about it, a person finds themselves counting random things around them. People with Counting OCD count for a variety of reasons. Many, many people have successfully found relief from the same symptoms you’re experiencing. I want to emphasize that you’re not alone, and that if compulsive counting is interfering in your life, your symptoms are not simply “the way it is” or part of your personality. People with Counting OCD may count to achieve a state of feeling “right” or “good” and to avoid the anxiety of something feeling “wrong” or “off.”Īs a specialist in OCD treatment, I know that people with counting symptoms may not recognize the full impact that compulsive counting behaviors can actually have-and how much relief can come from learning to manage their symptoms. Ever found yourself regularly counting the number of steps you take, counting and recounting the number of items in your grocery cart, or holding out for the clock to switch to a particular time to perform a certain task? These behaviors could all be a sign of Counting OCD, sometimes referred to as arithmomania.Ĭounting OCD is a common form of Obsessive-Compulsive Disorder, characterized by a strong urge to engage in repetitive and ritualistic counting behaviors. ![]() ![]() ![]() 6, 197–219, World Sientific Publishing Company (2013) Nakagava, Ion injectors for high-intensity accelerators. Stockli., Volume and surface-enhanced ion sources, Faircloth., Ion sources for high-power hadron accelerators, Komarov, Negative Ion Sources (NIIEFA, Review OD-4, Leningrad, 1976) М.А. Ehlers, Design considerations for high-intensity negative ion sources. Valter (ed.), Electrostatic Accelerators of Charged Particles (Gosatomizdat, Moscow, 1971). Alton, Negative ion formation and processes and sources, in Electrostatic Accelerators: Fundamentals and Applications, ed. On ion source and formation ion beam, BNL 50310, 237, Brookhaven, 1971. ![]() Dudnikov, Cross sections for stripping of-1-MeV negative hydrogen ions in certain gases. Semashko, Investigation and Development of Injectors of fast ions and atoms of Hydrogen for stationary Magnetic trap, Dissertation for Doctor of Fis-Mat nauk, IAE im. Semashko, Beams of Ions and Atoms for Controlled Nuclear Fusion and Technologies (Energoatomizdat, Moscow, 1986) М. Andersen, Atomic negative ions: Structure, dynamics and collisions. Tawara, Charge changing processes in hydrogen beams. Smirnov, Negative Ions (Mc Graw-Hill, New York, 1976) ![]() Hotop, Binding energies in atomic negative ions. Mac Daniel, Collision Processes in Ionized Gases (Mir, Moscow, 1967). Messy, Negative Ions (Cambridge University Press, 1976). Smirnov, Ions and Excited Atoms in Plasma (Atomizdat, Moscow, 1974). Smirnov, Atomic Collisions and Elemental Process in Plasma (Atomizdat, Moscow, 1968). Solpiter, Quantum Mechanics of Atoms with One and Two Electrons (Fismatgis, Moscow, 1960). Heeren, Negative ion source technology, in Plasma Technology, ed. Wolf, Handbook of Ion Sources (CRC Press, Boca Raton, 1995) Forrester, Large Ion Beams (Wiley, New York, 1988)ī. Brown (ed.), The Physics and Technology of Ion Sources (Wiley-VCH Verlag GmbH & Co. Zhang, Ion Sources (Springer, Switzerland AG, 1999) Gabovich, Physics and Technology of Plasma Ion Sources (Atomizdat, Moscow, 1972). Dudnikov, Development and Applications of Negative Ion Sources (Springer, Switzerland AG, 2019) Dudnikov, Negative Ion Sources (NSU, Novosibirsk, 2018). The equilibrium is reached when the number of molecules escaping from the liquid phase is the same as the number of molecules entering it.V. See įor instance, this kind of "fight" also happens with evaporation inside a closed recipient. The speed of bonds breaking and the speed of recombination "fight" one another, until they are in chemical equilibrium, that is when both speeds are the same. Note that even though H+ and OH- are naturally produced in water, they also recombine back into H2O. By the way, that is what makes both pH and pOH of water equal 7. that is: covalent bonds are breaking all the time (self-ionization), just like intermolecular bonds (evaporation). The concentration of each of these ions in pure water, at 25☌, and pressure of 1atm, is 1.0×10e−7mol/L. But, then, why no hydrogen or oxygen is observed as a product of pure water? Because water decomposes into H+ and OH- when the covalent bond breaks. Water, for example is always evaporating, even if not boiling. Yes, they can both break at the same time, it is just a matter of probability. Statistically, intermolecular bonds will break more often than covalent or ionic bonds. Intermolecular bonds break easier, but that does not mean first. ![]() ![]() ![]() In the rhythm game section of vivid/stasis, you'll find yourself facing various levels of difficulty, with many options for customizability to play the game your way. The game ties together an ongoing interweaving storyline with varying levels of music-based gameplay. Vivid/stasis is a rhythm-mystery hybrid game that follows the fates of four girls as they get wrapped up in a mind-bending adventure involving organizations, mysterious disappearances, and the fourth dimension. “Community feedback in our Discord server is read, if not always responded to, and we'll take any suggestions into account.”Ībout This Game And so, you find yourself here, at the apex of what we sought to achieve. How are you planning on involving the Community in your development process? vivid/stasis will always remain a free game experience.” Will the game be priced differently during and after Early Access? At Early Access Launch, Version 2.0 features the following modes: Free Play (Rhythm), Course Mode (Rhythm), and the first chapter of the game's episodic storyline.” “The game's main rhythm gameplay (and the accessibility / visual features associated with that mode) is present in the Early Access version. What is the current state of the Early Access version? We plan on releasing each episode and their additional songs throughout the Early Access period, with anticipation of the final episode being our last update before call the game a complete wrap.” “We plan on developing a full, complete story mode for the final, non-early access release of the game - a multi-episode narrative experience. How is the full version planned to differ from the Early Access version? “The current estimate for the team to have the main story completed in sometime in mid-2025.” Since it will be a while before the game is "complete" (all story content released), we've put the game in Early Access so players can play and form thoughts on new content as it gets finished.”Īpproximately how long will this game be in Early Access? As such, it takes quite a bit longer to develop than it would if we had a budget and worked on it full time. “vivid/stasis is a non-profit, story-based game. ![]() ![]() ![]() A vast array of presets has been carefully crafted to match the different genres of music so that you can simply dial into the audio to suit your moods.īoom 3D comes with Radio that gives you free access to more than 20,000 local and international Radio stations across 120 countries!ĭo you want some apps to be mute and other with a high volume? Boom 3D has an intelligent approach when it comes to controlling individual application volumes. ![]() The app has been outfitted with the most advanced Equalizers that allow you to modulate your audio with just the slide of your finger. Knowing the desires of Audiophiles, Boom 3D comes with a full-fledged audio player that allows you to organize your favorite tracks into playlists and enjoy the sensational studio quality sound, right on your Mac. This works system-wide so that your entire Mac OS X machine produces louder, better and enhanced volume all the time! It adds an extraordinary sense of depth to even the feeble notes making them BOOM with 3D!īoom 3D acts as a volume booster for Mac that takes audio levels up to deliver an enhanced audio experience. The app comes with a patent-pending 3D Surround Sound technology that offers a mind-blowing and immersive virtual surround sound that can be experienced on ANY headphones! You will be transported into your story while the audio will flow all around you with incredible realism. This results in the distinct perception of sound from different sources, that’s more immersive and lifelike than ever. Each audio channel’s fidelity and depth is enriched to be enjoyed on any standard stereo headphones, as well as full fledged 5.1 sound output hardware. With a sleek and intuitive interface, an extensive assortment of presets, an option to control the volumes of individual applications centrally and a wireless control (Boom Remote), Boom 3D gives you full control over the audio coming out of your Mac.īoom 3D supports the spatialization of 5.1 multichannel audio, no matter whether it’s from movies, music, or games. It automagically boosts all audio and creates the perfect sound profile for your Mac. If you want to convert your Mac into an entertainment powerhouse for videos, music, movies or games, Boom 3D is a must-have! Experience the Revolution!īoom 3D is a system-wide volume booster and equalizer for Mac that delivers an unbelievably realistic and immersive listening experience with its magical 3D Surround Sound and futuristic technology. Black Friday Madness Starts Now! Hurry, Limited Time OFFERĭive into the Future of Audio! Boom 3D Delivers Sound in 3D Dimensions. ![]() ![]() Does anyone have an updated script for this project? Or else does someone know how to fix the Encoders, import os, import sys, and so on? It seems I'm having to go line by line and find a solution to each. I rewrote from email.MIMEMultipart import MIMEMultipart to say from import MIMEMultipart, and same with MIMEBase and MIMEText However, it is now having issues with the import Encoders, and it basically seems to having problems with every. To fix these issues, - I did a Python update and then used sudo pip3 install imapclient and it stopped giving me some of the errors. 2.7 and it came back with imapclient errors, and it did not like the way email.MIMEMultipart and such is coded. Thanks for this tutorial! I got to the end of the project and am having a ton of issues with Python. We will use the Adafruit library for programming the LCD (more details on that later) There is a very nice detailed write up of the LCD wiring at One thing I love about this is that the top of the tin is flat, so they can’t just flip it over. Your dog will have to nudge the food around from all different angles. Muffin Tin So easy Turn a muffin tin upside down and spread kibble between the bumps. Pin #16 (LED -) goes to ground (black wire) Here are some of my favorite home-made food puzzles: 1. ![]()
![]() ![]() The method we are going to follow, is the same as installing Windows 10 on a Mac. However, some of the older Macs do support Boot Camp Assistant and you are able to install Windows 10 on them. iMac (Retina 4K, 21.5-inch) 2017 and upĪny other Mac doesn't have TPM 2.0 support.MacBook Pro (13-inch, Two Thunderbolt 3 ports) 2016 and up. ![]()
![]() ![]() Windows Server 2008 for 圆4-based Systems Service Pack 2 (Server Core installation) (3023562) Windows Server 2008 for 圆4-based Systems Service Pack 2 (Server Core installation) (3013455) Windows Server 2008 for 32-bit Systems Service Pack 2 (Server Core installation) (3023562) Windows Server 2008 for 32-bit Systems Service Pack 2 (Server Core installation) (3013455) Windows Server 2012 and Windows Server 2012 R2 Windows Server 2008 R2 for Itanium-based Systems Service Pack 1 (3023562) Windows Server 2008 R2 for Itanium-based Systems Service Pack 1 (3013455) Windows Server 2008 R2 for 圆4-based Systems Service Pack 1 (3023562) Windows Server 2008 R2 for 圆4-based Systems Service Pack 1 (3013455) Windows 7 for 圆4-based Systems Service Pack 1 (3023562) Windows 7 for 圆4-based Systems Service Pack 1 (3013455) Windows 7 for 32-bit Systems Service Pack 1 (3023562) ![]() Windows 7 for 32-bit Systems Service Pack 1 (3013455) Windows Server 2008 for Itanium-based Systems Service Pack 2 (3023562) Windows Server 2008 for Itanium-based Systems Service Pack 2 (3013455) Windows Server 2008 for 圆4-based Systems Service Pack 2 (3023562) Windows Server 2008 for 圆4-based Systems Service Pack 2 (3013455) Windows Server 2008 for 32-bit Systems Service Pack 2 (3023562) Windows Server 2008 for 32-bit Systems Service Pack 2 (3013455) Windows Vista 圆4 Edition Service Pack 2 (3023562) Windows Vista 圆4 Edition Service Pack 2 (3013455) Windows Server 2003 with SP2 for Itanium-based Systems (3023562) Windows Server 2003 with SP2 for Itanium-based Systems (3013455) Windows Server 2003 圆4 Edition Service Pack 2 (3023562) Windows Server 2003 圆4 Edition Service Pack 2 (3013455) Windows Server 2003 Service Pack 2 (3023562) Windows Server 2003 Service Pack 2 (3013455) To determine the support life cycle for your software version or edition, see Microsoft Support Lifecycle. Versions or editions that are not listed are either past their support life cycle or are not affected. The following software versions or editions are affected. For more information about the vulnerability, see the Vulnerability Information section.įor more information about this update, see Microsoft Knowledge Base Article 3036220. The security update addresses the vulnerabilities by correcting how the Windows kernel-mode driver validates certain parameters against registered objects, validates and enforces impersonation levels, handles objects in memory, validates data returned from user mode functions before being executed, handles TrueType Font error checking, and checks font widths prior to loading fonts into memory. For more information, see the Affected Software section. This security update is rated Critical for all supported editions of Windows 7, Windows Server 2008 R2, Windows 8, Windows Server 2012, Windows RT, Windows 8.1, Windows Server 2012 R2, and Windows RT 8.1 it is rated Important for all supported editions of Windows Server 2003, Windows Vista, and Windows Server 2008. The most severe of the vulnerabilities could allow remote code execution if an attacker convinces a user to open a specially crafted document or visit an untrusted website that contains embedded TrueType fonts. This security update resolves one publicly disclosed and five privately reported vulnerabilities in Microsoft Windows. Published: Febru| Updated: February 18, 2015 In this article Vulnerabilities in Windows Kernel-Mode Driver Could Allow Remote Code Execution (3036220) ![]() ![]() ![]() As Bruce Banner's love interest and a gifted scientist in her own right, Betty has hardly been referenced since her first and only appearance in The Incredible Hulk. Another shocking return from The Incredible Hulk franchise is Liv Tyler as Betty Ross. Samuel Sterns, played by Tim Blake Nelson and will likely take on the villainous role of The Leader. Ross is not the only character from The Incredible Hulk that will make an apperance. Ross will have a bigger role than ever in the film as he becomes the President of the United States and potentially even the Red Hulk. The iconic actor will make his MCU debut in Captain America: Brave New World, taking the role of Thaddeus “Thunderbolt” Ross, a baton passed down by the late William Hurt. In a conversation with Horowitz in March 2021 during the press tour for The Falcon and the Winter Soldier on the Comedy Central YouTube show. Next is the man who needs no introduction, Harrison Ford. Happy Sad Confused 's Josh Horowitz, Sam Wilson actor Anthony Mackie threw some shade at the current lifestyle of his former MCU co-star Chris Evans following his departure from the Captain America mantle. The film will be led by Anthony Mackie as Sam Wilson, the one and only Captain America. Like any other MCU features, the majority of the characters in Cap’s newest film originate from Phase 1 to 4. So, any further development of his character is bound to be engrossing, especially when faced with an opposing party - for what’s a superhero movie without a villain to defeat? That point aside, we’re once again reminded of what an eventful life Wilson has led. ![]() So, it’s starting with that emotional connection to Sam, and then seeing where it takes it.”įrom Onah’s description, it’s clear that this installment won’t be directly attached to the Captain America trilogy that concluded with Captain America: Civil War, which isn’t much of a surprise since, well, by this time, we all know that’s not how productions in Marvel Cinematic Universe roll. When you think about the journey that this character has taken in the MCU and the journey that Anthony has taken with the character in the MCU, I’m really excited to see this man go from a counselor, as an ex-Army vet, to a Falcon, to Captain America, and bring that set of experiences and that point of view into the decision-making that one has to make, as this incredibly powerful character in the MCU. Sam Wilson, played by Anthony Mackie, will take over the heroic identity from. “I was really drawn to Sam and his journey. Captain America will return to theaters next year in Marvel Studios Captain America: New World Order. The appointed director, Julius Onah, thankfully, has given us some clarity on that matter through an interview with Collider. ![]() ![]() ![]() The cuisine is now considered a must-have on most restaurant menus in Malaysia, especially the peninsular states. Tom yum, locally spelled as tomyam, is very well-received among Malaysians since its introduction around the 1980s. Depending on the type of tom som, the acidity can be derived from lime juice or from the use of tamarind. Tom som ( Thai: ต้มส้ม) are soups that are also very similar to tom yum but most often do not contain lemongrass or kaffir lime leaves. Less well known outside Thailand is tom khlong (ต้มโคล้ง), a spicy sour soup where the sourness does not derive from lime juice but through the use of tamarind. In restaurants in Thailand, Tom Yum comes in a fire pot with hot flame flaring from the chimney in the middle. The hot and spicy broth compliments well other Thai dishes. These require a long cooking time under low fire. Tom yam kha mu ( Thai: ต้มยำขาหมู), made with pork leg.Tom yam kung maphrao on nam khon ( Thai: ต้มยำมะพร้าวอ่อนน้ำข้น), a version of prawn tom yum with the meat of a young coconut and a dash of (coconut) milk.Tom yam po taek ( Thai: ต้มยำโป๊ะแตก) or tom yam thale ( Thai: ต้มยำทะเล) is a variant of the soup with mixed seafood, like prawns, squid, clams and pieces of fish.Tom yam gai ( Thai: ต้มยำไก่) is the chicken version of the soup.Usually fish with firm flesh that doesn't crumble after boiling is preferred for this type of soup. It used to be the most widespread form of tom yam before mass-tourism came to Thailand, for fresh fish is readily available almost everywhere in the region's rivers, canals and lakes as well as in the sea. Tom yam pla ( Thai: ต้มยำปลา) is a clear fish soup that was traditionally eaten with rice.The dish originated during the Rattanakosin Kingdom. Tom yam kung ( Thai: ต้มยำกุ้ง) – the version of the dish most popular among tourists, is made with prawns as the main ingredient.Tom yam kathi ( Thai: ต้มยำกะทิ) – coconut milk-based tom yum-this is often confused with tom kha kai ("chicken galanga soup"), where galangal is the dominant flavour of the coconut milk-based soup.common with prawns as a main ingredient, evaporated milk or non-dairy creamer powder is added to the broth as a finishing touch. Tom yam nam khon ( Thai: ต้มยำน้ำข้น) is a more recent variation from the 1980s.Tom yam nam sai ( Thai: ต้มยำน้ำใส), clear broth tom yam soup.Selected types Tom yam kung maphrao on nam khon, as served in Uttaradit, Thailand Ready-to-use bundles of lemongrass, galangal, lime leaves, and, for chicken tom yam, also turmeric, are sold at Thai markets The soup is often topped with a generous sprinkling of fresh chopped coriander leaves, and may be served over a serving of rice. ![]() Yet other ingredients may also be used, depending on the exact variety of tom yam, such as evaporated milk. This imparts sweet, salty, and spicy tastes. For most varieties a paste called nam phrik phao ( Thai: น้ำพริกเผา) is also added, made from shrimp, chilis, shallots, and garlic. When the meat is cooked, final flavorings whose taste is destroyed by heat, such as fish sauce and lime juice, are added. Various meats are added next, commonly fish, shrimp, mixed seafood, pork, or chicken. In modern popular versions the soup may also contain mushrooms-usually straw mushrooms or oyster mushrooms. Vegetables are then added, such as onion and tomato. The paste is bottled or packaged and sold around the world. This is made by crushing all the herb ingredients and stir frying in oil, then adding seasoning and other preservative ingredients. Īlternatively, commercial tom yum paste may be used. However they may be left in, as an aid to presentation. These ingredients are often then removed as their flavor is now extracted and many aren't edible. For shrimp-based soups, shrimp shells and heads may also be simmered, to extract their flavor. These include fresh ingredients such as lemongrass, kaffir lime leaves, galangal, chilis, shallots, and garlic. Various aromatic ingredients are sliced, roughly pounded, and simmered to extract their flavor. The soup base depends on the exact sub-type but is generally water, coconut milk, or chicken or other broth. Tom refers to the boiling process, while yam means 'mixed'. The name "tom yam" is composed of two Thai words. And it has a strong flavors in Thai food offer that make them very popular. It is a soup that normally includes shrimp in a hot and sour serving. Tom yum or tom yam ( UK: / ˌ t ɒ m ˈ j æ m, - ˈ j ʌ m/, US: /- ˈ j ɑː m/ Thai: ต้มยำ, RTGS: tom yam ⓘ) is a family of hot and sour Thai soups. ![]() |
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